BRAND NAME-VOMYFLO TABLETS
COMPOSITION: DOXYLAMINE 10MG + PYRIDOXINE 10MG + FOLIC ACID 2.5MG TABLETS
Doxylamine is in the first-generation histamine receptor H1 antagonist class of medications.
Doxylamine is a medication used to manage and treat nausea and vomiting of pregnancy (NVP), allergic rhinitis, and insomnia.
MECHANISM OF DOXYLAMINE
As a member of the first-generation class of antihistamines, doxylamine exerts its effects by competitively antagonizing the binding of free histamine at the H1-receptor binding sites. It antagonizes the effects of histamine in the uterus, GI tract, large blood vessels, and bronchial muscles. Doxylamine binds non-selectively to H1-receptors, both centrally and peripherally, contributing to the sedative effects that also make it an effective sleeping aid.
Doxylamine reduces nausea and vomiting by inhibiting histaminergic signaling to the vomiting center in the medulla.
Pyridoxine is the 4-methanol form of Vitamin B6, an important water-soluble vitamin that is naturally present in many foods. As its classification as a vitamin implies, Vitamin B6 (and pyridoxine) are essential nutrients required for normal functioning of many biological systems within the body.
Pyridoxine is indicated for the treatment of Vitamin B6 deficiency and for the prophylaxis of -induced peripheral neuropathy. It is also recommended for treatment of nausea and vomiting in pregnancy in a combination with doxylamine.
Folate (vitamin B9) is an essential nutrient that is required for DNA replication and as a substrate for a range of enzymatic reactions involved in amino acid synthesis and vitamin metabolism. Demands for folate increase during pregnancy because it is also required for growth and development of the fetus. Folate deficiency has been associated with abnormalities in both mothers (anemia, peripheral neuropathy) and fetuses (congenital abnormalities).