DROTAVERINE 80MG +MEFENAMIC ACID 250 MG TABLETS

BRAND NAME: DUDOT-M TABLETS

COMPOSITION: DROTAVERINE HCL 80MG +MEFENAMIC ACID 250 MG TABLETS

PACKING: 10*10 BLISTER

DROTAVERINE

Drotaverine is an antispasmodic drug having class phosphodiesterase-4 inhibitor used to alleviate gastrointestinal and genitourinary smooth muscle spasms.

Drotaverine has been used in the symptomatic treatment of various spastic conditions, such as gastrointestinal diseases, biliary dyskinesia, and vasomotor diseases associated with smooth muscle spasms. It also has been investigated in dysmenorrhea, abortion,  and augmentation of labour.

Drotaverine is used to reduce and relieve muscle spasms in the gastrointestinal tract, urinary tract, and gall bladder.

MECHANISM OF DROTAVERINE

DROTAVERINE inhibits phosphodiesterase-IV which is specific for smooth muscle. It has direct and rapid action on the smooth muscles. DROTAVERINE corrects the cyclic AMP and calcium imbalance at the spastic site. Thereby relieves pain and muscle spasms.

MEFENAMIC ACID

Mefenamic acid belongs to the anthranilic acid derivative class of NSAIDs . Like other NSAIDs, mefenamic acid is a cyclo-oxygenase (Cox-1 and -2) inhibitor and blocks the production of intracellular prostaglandins that are important in pain and inflammatory pathways.

Mefenamic acid has analgesic as well as antipyretic and antiinflammatory activities, but is used largely for treatment of pain.

 Mefenamic acid is indicated for the treatment of mild-to-moderate acute pain or dysmenorrhea,  painful conditions such as  arthritis, pain associated with heavy menstrual bleeding and pain after surgical operations.

COMMON SIDE EFFECT OF MEFENAMIC ACID

  • stomach pain
  • nausea
  • vomiting
  • heartburn
  • constipation
  • diarrhea
  • rash
  • dizziness
  • tinnitus (ringing in your ears)

INDICATIONS OF DUDOT-M TABLETS

1.Dysmenorrhea

2. Pelvic Pain

3.Post surgicanl uterine spasm

4.Spasmodic pain of any other origin

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