BRAND NAME: VULVOFEN -600 VAGINAL SOFTGELS
COMPOSITION: FENTICONAZOLE 600MG VAGINAL SOFTGELS
PACKING-1*30 CAPSULES (BLISTER PACKING)
•Pharmacotherapeutic group : broad-spectrum imidazole antimycotic agent with high fungistatic and fungicidal activity against dermatophytes (all species of Trichophyton, Microsporum, Epidermophyton), Candida albicans and other mycotic agents of the skin and the mucosa.
•FENTICONAZOLE have antibacterial activity against Gram positive bacteria and an antiparasitic action against Trichomonas vaginalis.
•MECHANISM OF ACTION-
VULVOFEN (Fenticonazole) shows unique multimodal action against Candida species involving:
1. Inhibition of secretary aspartate protenase (SAP) there by preventing the growth, adherence,and penetration of Candida sp.
•2. Inhibits fungal cytochrome P450 3A enzyme, lanosine 14α-demethylase responsible for conversion of lanosterol to ergosterol, the main sterol attributed to fungal cell membrane integrity and cell survival.
•3. Inhibits complimentary oxidase and peroxidase enzymes that lead to structural and functional changes in fungal cell due to its antioxidant action.
•Similarly, fenticonazole inhibits the growth of bacterial (Gardenella vaginalis) and Protozoan (Trichomonas sp.) by inhibition of pyruvate oxido reductase enzyme responsible for cell division or replication.
•INDICATIONS OF VULVOFEN VAGINAL CAPSULES:
1) Vulvovaginal Candiasis.
Vulvovaginal candidiasis is a global issue of concern due to its association with economic costs, sexually transmitted infections, and ascending genital tract infection.
Candidiasis is an infection caused by a yeast (a type of fungus) called Candida. Candida normally lives inside the body (in places such as the mouth, throat, gut, and vagina) and on skin without causing any problems. Sometimes Candida can multiply and cause an infection if the environment inside the vagina changes in a way that encourages its growth.
Candidiasis in the vagina is commonly called a “vaginal yeast infection.” Other names for this infection are “vaginal candidiasis,” “vulvovaginal candidiasis,” or “candidal vaginitis.”
- Vaginal itching or soreness
- Pain during sexual intercourse
- Pain or discomfort when urinating
- Abnormal vaginal discharge
2) Vaginal thrush:
Most cases of thrush are caused by the yeast called Candida albicans but other types of Candida spp. can also cause thrush.
• Common symptoms of vaginal thrush are itching, soreness, and redness around the outside of the vagina and a thick, creamy white, odourless vaginal discharge.
•Fenticonazole has also been shown to exhibit antibacterial action, with a spectrum of activity that includes bacteria commonly associated with superinfected fungal skin and vaginal infections, and antiparasitic action against the protozoan Trichomonas vaginalis.
•It is an ideal topical alternative to multi-agent treatment of mixed infections involving mycotic, bacterial, dermatophyte and/or Trichomonas spp.
•very well tolerated, with no reports of appreciable local or systemic adverse reactions.
•short course therapy benefits that can be safely given to high-risk patients including pregnancy albeit from second trimester onward.
One 600 mg soft vaginal capsule should be inserted deeply into the vagina at bedtime. A second administration can be repeated after three days if symptoms persists