LEVONORGESTREL IP 0.15 MG + ETHINYLOESTRADIOL IP 0.03 MG TABLETS

BRAND NAME: PREGAMASH-L TABLETS

COMPOSITION: LEVONORGESTREL IP 0.15 MG + ETHINYLOESTRADIOL IP 0.03 MG

PACKING:12*1*21 TABLETS BLISTER PACK

LEVONORGESTREL

Levonorgestrel is FDA-approved to be used within 72 hours of unprotected sexual intercourse or when a presumed contraceptive failure has occurred. A prescription is not needed, and it is available over the counter at local pharmacies.

The FDA has also approved levonorgestrel availability for all age groups due to its lack of life-threatening contraindications and side-effect profile.Levonorgestrel can be used as an oral combination pill with estradiol as a long-term option for birth control.

MECHANISM OF LEVONORGESTREL

Levonorgestrel is a second-generation synthetic progestogen that is the active component of the racemic mixture of norgestrel. It binds to progesterone and androgen receptors, where it can delay gonadotropin-releasing hormone from being released from the hypothalamus. This action blunts the luteinizing hormone surge that occurs during the pre-ovulation stage. Ultimately, it can delay or inhibit ovulation by preventing fertilization via inhibiting follicular rupture and releasing a viable egg from the ovaries.

Optimal efficacy is achievable when it is taken in the pre-ovulation stage as well. Levonorgestrel also induces the thickening of cervical mucus, which helps by interfering with sperm motility and passage. 

ETHINYLOESTRADIOL

MECHANISM OF ETHINYLOESTRADIOL

Ethinylestradiol is a semisynthetic steroid estrogen, used in combination with progestogen as an oral contraceptive.

It was developed in an effort to create an estrogen with greater oral bioavailability. These properties were achieved by the substitution of an ethinyl group at carbon 17 of  estradiol. Ethinylestradiol soon replaced  mentranol in contraceptive pills.


Ethinylestradiol is combined with other drugs for use as a contraceptive, premenstrual dysphoric disorder, moderate acne, moderate to severe vasomotor symptoms of menopause, prevention of postmenopausal osteoporosis

Combined oral contraceptives suppress ovulation by suppressing gonadotrophic hormone, thickening cervical mucus to prevent the travel of sperm, and preventing changes in the endometrium required for implantation of a fertilized egg. Ethinylestradiol decreases luteinizing hormone, decreasing vascularity in the endometrium.

INDICATION OF PREGAMASH-L TABLETS

Contraceptive pills to reduce the chances of pregnancy after unprotected sex.

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