BRAND NAME-ALNAMET-OVA TABLETS
COMPOSITION: MYO-INOSITOL 550MG + D-CHIRO INOSITOL 13.8MG + METFORMIN 500MG + L-METHYL FOLATE CALCIUM 0.5MG + METHYLCOBALAMIN 750MCG
PACKING: 10*10 STRIP PACKING
POLY CYSTIC OVARY SYNDROME (PCOS)
PCOS is a heterogeneous endocrine, reproductive and metabolic disorder, affecting at least 5–10% of the total population of reproductive-age women, worldwide . Independently of body habitus , women with PCOS manifest a 50–70% incidence of IR, resulting in a compensatory hyperinsulinemia, which derives many of the phenotypic features of this disease.
PCOS encompasses a broad spectrum of biochemical/clinical signs and symptoms such as irregular menstrual cycles, polycystic ovaries, acne, overweight, androgen excess with consequent hirsutism and as aforementioned IR . It is also associated with several long-term health consequences, including obesity , infertility , obstetric complications , type 2 diabetes , cardiovascular disease , psychological distress and ostensibly mood disorders.
It is noteworthy that improvement of insulin resistance and reduction of circulating insulin are key therapeutic targets in PCOS , enhancing fertility and reducing the lifelong risk for type 2 diabetes and early cardiovascular disease. Besides metformin,myo-inositol is now considered as a further insulin-sensitizing supplement which could benefit women with PCOS.
Myo-inositol (MI) is one stereoisomer of a C6 sugar alcohol that belongs to the inositol family . It is the precursor of inositol triphosphate, acting as an intracellular second messenger and regulating a number of hormones such as thyroid-stimulating hormone, follicle-stimulating hormone (FSH) and insulin
Myo-inositol (MI) supplementation in women with polycystic ovary syndrome (PCOS) has been evaluated over the last years. Many hormonal and reproductive impairments associated with this disorder seem relieved by the supplement.
Myo-inositol modulates the activation of glucose transporters and glucose utilization, and glycogen synthesis takes place under the control of d-chiro-inositol (DCI). This molecule on the ovary regulates the insulin-induced androgen synthesis, whereas MI regulates glucose uptake and FSH signaling .
MI has been used to prevent and/or treat a number of metabolic disorders related to insulin resistance, such as the metabolic syndrome , gestational diabetes mellitus and the polycystic ovary syndrome (PCOS).
D-chiro-inositol (commonly abbreviated DCI) is a member of a group of molecules collectively called inositols.
In lean women with the polycystic ovary syndrome, D-chiro-inositol reduces circulating insulin, decreases serum androgens, and ameliorates some of the metabolic abnormalities (increased blood pressure and hypertriglyceridemia) of syndrome X.
VARIOUS ROLES OF D-CHIRO INOSITOL
- mediates the action of insulin;
- it is involved in the synthesis of insulin-dependent androgens;
- promotes glucose storage;
- acts as an aromatase modulator
Polycystic ovary syndrome (PCOS) is an endocrinopathy characterised by increased resistance to insulin. Metformin is one of the longest established oral insulin sensitising agents. For decades its use was restricted to management of type 2 diabetes. However, in the past two decades, its properties as an insulin sensitising agent have been explored in relation to its applicability for women with PCOS.
Metformin is an effective ovulation induction agent for non-obese women with PCOS and offers some advantages over other first line treatments for anovulatory infertility such as clomiphene. For clomiphene-resistant women, metformin alone or in combination with clomiphene is an effective next step.
L-METHYL FOLATE CALCIUM
Calcium L-methylfolate is a source of folate and an alternative to folic acid for use in human food and food supplements.
Maintaining an adequate folate status is particularly important during periods of rapid cell proliferation and tissue growth such as gestation and infancy. Folate deficiency has been associated with increased risk for neural tube defects, certain chronic diseases and cancer.
Vitamin B6 and vitamin B12 have significant roles in homocysteine (Hcy) regulation. In the pathophysiology of PCOS, a positive correlation has been reported between IR and elevated Hcy levels. Kaya et al. demonstrated that IR, obesity, and increased Hcy levels were related to low serum insulin B12 concentrations in women with PCOS. In order to reduce elevated levels of serum Hcy, folic acid supplementation for 3 months produced effective results, especially in women without insulin resistance.
Metformin inhibits the binding intrinsic factor–B12 complex and its receptor, and also serum vitamin B12 and folic acid levels
decrease during metformin therapy. Metformin increases Hcy levels. Supplements of vitamins had no effects on androgen and
lipid levels in the pathophysiology of PCOS.
BENEFITS OF ALNAMET-OVA TABLETS
- Enhances the body’s response to insulin
- Lowers high levels of homocysteine
- It also helps in improving hormonal balance, follicular development, improves egg quality, regulates menstruation, and restores ovulation in women.