BRAND NAME: WISENOR-CR TABLETS
COMPOSITION: NORTHISTERONE/NORTHINDRONE 10 MG TABLETS
PACKING: 10*10 ALU-ALU
•Northisterone is a man-made form of progesterone (a naturally occurring female sex hormone).
• At low dose (≤1 mg a day) it can be use in combination with estrogens either as a contraceptive or in hormone replacement therapy.
•At higher dose (≥5 mg daily) it can be used for menorrhagia, to treat metropathia haemorrhagica, and to postpone menstruation.
Norethisterone mimics the actions of endogenous progesterone, albeit with a greater potency, and is used on its own or in combination with estrogen derivatives in a variety of applications including contraception and hormone replacement therapy.
MECHANISM OF NORTHISTERONE
Why Northisterone is superior alternative to oral contraceptives?
•Delay menstruation without causing spotting.
•Unlike contraceptives, norethindrone allows for an immediate return to fertility after discontinuation.
•Norethindrone has minimal pro-coagulant effects, making it an excellent choice in patients at risk for VTE or cardiovascular disease.
•Ovulation blocking effect 11 to 25 times more potent than levonorgestrel and medroxyprogesterone acetate respectively.
•at clinical doses, norethisterone has hardly any androgenic effect.
•Safer long-term use with minimal toxic effect.
INDICATIONS OF WISENOR-CR TABLETS
1. Abnormal uterine bleeding
2.Amenorrhea: is the absence of menstruation, often defined as missing one or more menstrual periods
3. Endometriosis: an often painful disorder in which tissue similar to the tissue that normally lines the inside of your uterus — the endometrium — grows outside your uterus. Endometriosis most commonly involves your ovaries, fallopian tubes and the tissue lining your pelvis.
4.Contraception: prevent pregnancy.