TRANEXAMIC ACID 250 MG + ETHAMSYLATE 250 MG TABLETS

BRAND NAME: RAUF-E TABLETS

COMPOSITION: TRANEXAMIC ACID 250 MG + ETHAMSYLATE 250 MG TABLETS

PACKING: 10*10 BLISTER PACK

TRANEXAMIC ACID


Tranexamic acid
 is an antifibrinolytic used to reduce or prevent hemorrhagic episodes, especially in the context of hyperfibrinolytic disorders.It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent.

Taken orally, tranexamic acid is indicated for the treatment of hereditary angioedema, cyclic heavy menstrual bleeding in premenopausal females, and other instances of significant bleeding in the context of hyperfibrinolysis.

MECHANISM OF TRANEXAMIC ACID

Tranexamic acid competitively and reversibly inhibits the activation of plasminogen via binding at several distinct sites, including four or five low-affinity sites and one high-affinity site, the latter of which is involved in its binding to fibrin. The binding of plasminogen to fibrin induces fibrinolysis – by occupying the necessary binding sites tranexamic acid prevents this dissolution of fibrin, thereby stabilizing the clot and preventing hemorrhage

ETHAMSYLATE

Ethamsylate is a synthetic hemostatic drug indicated in cases of capillary bleeding.

well-controlled clinical trials clearly showed the therapeutic efficacy of ethamsylate in dysfunctional uterine bleeding, with the magnitude of blood-loss reduction being directly proportional to the severity of the menorrhagia. Other well-controlled clinical trials showed therapeutic efficacy of ethamsylate in periventricular hemorrhage in very low birth weight babies and surgical or postsurgical capillary bleeding.

MECHANISM OF ACTION OF ETHAMSYLATE

Ethamsylate acts on the first step of hemostasis by improving platelet adhesiveness and restoring capillary resistance. Recent studies showed that ethamsylate promotes P-selectin-dependent, platelet adhesive mechanisms.

Ethamsylate as an hemostatic agent is a mild but well-tolerated drug, particularly useful in dysfunctional uterine bleeding when contraception is not needed.

INDICATIONS OF RAUF-E TABLETS

  1. Dysfunctional bleeding.
  2. Menorrhagia.
  3. Metrorrjagia.
  4. Post-abortion bleeding.
  5. Post-partum hemorrhages.
  6. Intra uterine contraceptivec induced menorrhagia.

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